COVID-19 is rapidly spreading worldwide and specific literature how to deal with IBD patients is limited so far. Here, the World Endoscopy Organisation (WEO) is providing practical advice for the management of IBD patients during the pandemic covering the diagnostic and therapeutic spectrum. This article is protected by copyright. All rights reserved.A homoleptic organometallic Fe(IV) complex that is stable in both solution and in the solid state at ambient conditions has been synthesized and isolated as [Fe(phtmeimb) 2 ](PF 6 ) 2 (phtmeimb = [phenyl(tris(3-methylimidazolin-2-ylidene))borate] - ). This Fe(IV) N -heterocyclic carbene (NHC) complex was characterized by 1 H NMR, HR-MS, elemental analysis, scXRD analysis, electrochemistry, Mößbauer spectroscopy, and magnetic susceptibility. The two latter techniques unequivocally demonstrate that [Fe(phtmeimb) 2 ](PF 6 ) 2 is a triplet Fe(IV) low-spin S =1 complex in the ground state, in agreement with quantum chemical calculations. The electronic absorption spectrum of [Fe(phtmeimb) 2 ](PF 6 ) 2 in acetonitrile shows an intense absorption band in the red and near IR, due to LMCT (ligand-to-metal charge transfer) excitation. For the first time the excited state dynamics of a Fe(IV) complex was studied and revealed a ~0.8 ps lifetime of the 3 LMCT excited state of [Fe(phtmeimb) 2 ](PF 6 ) 2 in acetonitrile. © 2020 WILEY-VCH Verlag GmbH &amp; Co. KGaA, Weinheim.INTRODUCTION Advanced gynecologic cancers have a poor prognosis and constitute a major challenge for adequate treatment strategies. By analyzing and targeting molecular alterations, molecular guided treatments may be a viable option for the treatment of advanced gynecologic cancers. PATIENTS AND METHODS In this single-center, real-world retrospective analysis of our platform for precision cancer medicine (PCM), we describe the molecular profiling of 72 patients diagnosed with different types of advanced gynecologic malignancies. Tumor samples of the patients were examined by next-generation sequencing panel and immunohistochemistry (IHC). RESULTS In total, we identified 209 genetic aberrations in 72 patients. https://www.selleckchem.com/products/bgj398-nvp-bgj398.html The ten most frequent alterations were TP53 (n =?42, 20%), KRAS (n =?14, 6.6%), PIK3CA (n =?11, 5.2%), PIK3R1 (n =?9, 4.3%), ATR (n =?8, 3.8%), PTEN (n =?8, 3.8%), BRCA1 (n =?6, 2.8%), NF1 (n =?4, 1.9%), NOTCH1 (n =?4, 1.9%), and POLE (n =?4, 1.9%), which account for more than half of all molecular alter© 2020 The Authors. The Oncologist published by Wiley Periodicals, Inc. on behalf of AlphaMed Press.The COVID-19 pandemic has changed our perspective on a myriad of things as it sweeps across the globe. One issue we are forced to pay more attention to is the risk that COVID related care entails and the fact that nurses have tragically lost their lives in this pandemic (Cook et al 2020). This loss of life has included student nurses (Ford 2020). This article is protected by copyright. All rights reserved.In recent years, research has increasingly focused on the key role of posttranscriptional regulation of mRNP function and turnover. Due to their complexity and dynamic nature, the full composition of a single mRNP complex remains unrevealed and mRNPs are poorly described in plants. Here we identify canonical Sm proteins as part of the cytoplasmic mRNP complex indicating their function in the posttranscriptional regulation of gene expression in plants. Sm proteins comprise an evolutionarily ancient family of small RNA-binding proteins involved in pre-mRNA splicing. The latest research indicates that Sm could also impact on mRNA at subsequent stages of its life cycle. In this work we show that in the larch microsporocyte cytoplasm, Sm proteins accumulate within distinct cytoplasmic bodies, also containing polyadenylated RNA (poly(A) RNA). To date, several types of cytoplasmic bodies involved in the posttranscriptional regulation of gene expression have been described, mainly in animal cells. However, their role and molecular composition in plants remain less established. 222 mRNA transcripts have been identified as cytoplasmic partners for Sm proteins. The specific colocalization of these mRNAs with Sm proteins within cytoplasmic bodies has been confirmed via microscopic analysis. The results from this work support the hypothesis, that evolutionarily conserved Sm proteins have been adapted to perform a whole repertoire of functions related to the posttranscriptional regulation of gene expression in Eukaryota. This adaptation presumably enabled them to coordinate the interdependent processes of splicing element assembly, mRNA maturation and processing, and mRNA translation regulation, and its degradation. This article is protected by copyright. All rights reserved.Nitrogen (N) is a major factor for plant development and productivity. However, the application of nitrogenous fertilizers generates environmental and economic problems. To cope with the increasing global food demand, the development of rice varieties with high nitrogen use efficiency (NUE) is indispensable to reduce environmental issues and achieve sustainable agriculture. Here, we report that the concomitant activation of the rice (Oryza sativa) Ammonium transporter 1;2 (OsAMT1;2) and Glutamate synthetase 1 (OsGOGAT1) genes leads to increased tolerance to nitrogen-limitation and to better ammonium uptake and N-remobilization at the whole plant level. We show that the double activation of OsAMT1;2 and OsGOGAT1 increases plant performance in agriculture, providing better N grain filling without yield penalty under paddy field conditions, and better grain yield and N content when plants are grown under N-limiting in field conditions. Combining OsAMT1;2 and OsGOGAT1 activation then provides a good breeding strategy for improving plant growth, nitrogen use efficiency and grain productivity especially under nitrogen limitation through the increment of both nitrogen uptake and assimilation. This article is protected by copyright. All rights reserved.The widespread XoxF, a recently discovered methanol dehydrogenase enzyme used by methylotrophic bacteria to oxidize methanol for carbon and energy, requires lanthanide ions for its activity. This enzyme represents an essential component of methanol utilization by both methanol- and methane-utilizing bacteria. The present investigation looks on the electronic, energetical and geometrical behavior of the methanol dehydrogenase from Methylacidiphilum fumariolicum SolV strictly dependent on early lanthanide metals with +3 oxidation states by examining enzyme-substrate complexes of all the lanthanides and focusing the attention on the catalytic reaction mechanism of two methanol dehydrogenases having as cofactor europium and ytterbium belonging to the in mid- and later- series of the lanthanides, in comparison with the methanol dehydrogenase containing the cerium, one early lanthanide. Our outcomes evidence the influence of the lanthanide contraction effect in all the elementary steps of the catalytic reaction mechanism.